TECNO_EN-P, a system to create smart membranes

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Laboratory
TPM - TECNOPOLO MIRANDOLA "Mario Veronesi"
Contacts
Massimo Dominici
Specialization Area
Health and Wellness
Keyword
smart material
medical device
Logo TECNO_EN
Innovative aspects

The functionalized smart materials could favor the development of new MD with better therapeutical performance, that can be used for different application in the biomedical and clinical field. In fact, until today, the removal of cells and other biological components is carried out by non-selective technologies and this can cause the loss of different biological elements. Thanks to the set-up of smart materials, that act in a selective way, only the interested elements will be selected ensuring a safer treatment for the treated patient.

Potential applications

Thanks to the use of these kind of smart materials, a new generation of medical devices will be developed with a controllable specificity and higher selectivity/performance compared to the solutions currently on the market. This will allow the set-up of specific and personalised therapeutical approach.

Imagine of biocompatible and filtering material
Application example

New technologies for innovative and smart membranes

Application description and results

TECNO_EN-P aims to develop new technologies to improve existing filtration systems. Until today, 4 different applications are identified: Specific selection of mesenchymal stem cells from adipose tissue (MSC); Selective removal of circulating tumour cells from intraoperative recovery blood; Selective removal of lipid suspensions from intraoperative blood; Removal of precipitate in therapeutic apheresis systems. The obtained solutions can enhance some therapeutic approaches (in certain pathologies where the removal of biological material / cells is the therapy) and the diagnostic methods through the analysis of the selected and isolated material. The evaluation of these smart membranes consisted of: - Removal performance, to evaluate if the performances are compatible with the specific areas of application; - Safety, through biocompatibility tests required by ISO 10993 and according to innovative approaches with tests developed at the TPM to obtain innovative devices applicable to the medical-health sector; - Production method, that has to be compatible with the existing one and considering different aspects such as sterilization, transport, storage and final cost of the product.

Involved partners

CIRI SdV CIRI MAM FONDAZIONE DEMOCENTER-SIPE

Implementation Time
24 months from the idea to the TRL5 product
Technology Readiness Level
TRL5 - Technology validated in relevant environment (industrially relevant environment in the case of key enabling technologies)
Exploitation

Four prototypes are made for different applications; patent application ongoing for one of them

Functionalized membranes for lipids sequestration
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