TECNOPOLO DI BOLOGNA - OZZANO, Via Tolara di Sopra 41/E - Ozzano (BO)
IRET Foundation is a scientific research organization in the biomedical field, dedicated to the study of diseases “without cure” such as degenerative diseases and injuries of the central nervous system (multiple sclerosis, Alzheimer’s dementia, vascular dementias, ataxias, Parkinson’s disease, traumatic injuries and vascular lesions of the brain and spinal cord, chronic pain). It conducts research in the areas of neurology, rare and dysmetabolic diseases, regenerative medicine, drug discovery, development and screening, advanced therapies, and tissue engineering.
IRET has extensive experience in modeling in vitro (cell lines, primary cells, and stem cells cultured with 2D and 3D techniques) and in vivo (transgenic animals, surgically induced lesions, chemical, immunological). The research carried out aims to identify innovative strategies to counteract the progression of diseases, repair their damage, and identify causes to prevent their occurrence.
It has a large facility for animal experimentation (rats and mice), equipped with an operating room and laboratories for the study of complex behaviors; laboratories for cell cultures, molecular biology, proteomics. It has a major facility for advanced microscopy and computerized image analysis in 2D, 3D, 4D.
The IRET Foundation has signed research collaboration agreements with several departments of the University of Bologna and Ferrara and with hospitals in the Region. IRET also has agreements with the Montecatone Rehabilitation Institute in Imola and the ISMETT Institute/Ri.MED Foundation in Palermo.
The IRET Foundation is the Ozzano dell’Emilia branch of the Bologna Technopole named after Rita Levi-Montalcini.
Chiesi Farmaceutici, Parma;
APR Applied Pharma Research, Swiss;
Zymenex Sweden/Danmark (ora Chiesi Group);
FremsLife, Genova;
Maria Cecilia Hospital, Cotignola, gruppo GVM;
Igea, Carpi;
Casa di Cura Privata del Policlinico, Milano;
Montecatone Rehabilitation Institute, Montecatone;
Biofer, Medolla;
ISMETT/Fondazione Ri.MED, Palermo.
Biosensors
- 2D, 3D and 4D imaging and quantification - Laura Calzà
- Cell based high content imaging and screening - Laura Calzà
Devices and prostheses
- Microscopic/nanoscopic/nanomechanical, mechanical and in vitro functional characterization of the device - Laura Calzà
- In vivo functional characterization of the device - Luciana Giardino
- Analysis by means of molecular biology as well as biochemical, immunoenzymatic, histologic, immunohistochemical, biomechanical, radiographic - Laura Calzà
- Evaluation of the bio-safety of medical devices in vitro - Luciana Giardino
Drug delivery
- Tecnological controls, in vitro and stability tests omn oral formulations - Luciana Giardino
- In vitro deposition and drug release and stability of inhalatory formulations - Luciana Giardino
- In vitro drug release of nanoparticles and complex scaffolds - Laura Calzà
- In vitro evaluation of the cell response to drug delivery systems - Laura Calzà
Drug discovery
- Drug study on cells of the human nervous system - Laura Calzà
- Drug study on animal embrional stem cells cells - Laura Calzà
- Drug study on human and animal fibroblasts - Laura Calzà
Omics
- Sample processing - Maura Cescatti
- Transcriptomics - Maura Cescatti
- Proteomics - Maura Cescatti
- Identification and validation of biomarkers - Maura Cescatti
Preclinical studies
- Test of proliferation, migration, differentiation, adhesion, viability, cell apoptosis - Luciana Giardino
- Test of proliferation, migration, differentiation, adhesion, viability, cell apoptosis (high-content) - Luciana Giardino
- Test of proliferation, migration, differentiation, adhesion, viability, cell apoptosis (ISO 9001 and GLP) - Luciana Giardino
- Quantitative cell morphology test - Laura Calzà
- Quantitative cell morphology test (high-content) - Laura Calzà
- Quantitative cell morphology test (ISO 9001, GLP) - Laura Calzà
- Dynamic imaging - Laura Calzà
- Dynamic imaging (high-content, ISO 9001, GLP) - Laura Calzà
- Behavior animal testing for learning and memory and/or locomotion - Luciana Giardino
- Behavior animal testing for learning and memory and/or locomotion with video tracking - Luciana Giardino
- Behavior animal testing for learning and memory and/or locomotion (ISO 9001, GLP) - Luciana Giardino
- behavior animal tests for acute and chronic pain in animal free to move - Luciana Giardino
- behavior animal tests for acute and chronic pain in animal free to move with video tracking - Luciana Giardino
- behavior animal tests for acute and chronic pain in animal free to move (ISO 9001, GLP) - Luciana Giardino
- Animal tests of gastrointestinal function - Luciana Giardino
- Histological and immunohistochemical evaluations - Laura Calzà
- Histological and immunohistochemical evaluations (quantitative computed) - Laura Calzà
- Histological and immunohistochemical evaluations (ISO 9001, GLP) - Laura Calzà
Scaffold
- Design and development of scaffolds for soft tissue regeneration - Laura Calzà
- Design of protocols for pre-clinical evaluation (in vitro and in vivo) - Laura Calzà
- Design and development of nanofibrous scaffolds mimicking the extracellular matrix - Laura Calzà
- Deposition of thin films and coatings - Laura Calzà
- Scaffold functionalization with proteins, drugs and cells - Luciana Giardino
Advanced Therapies
- Advanced Therapy Design (nervous cells) - Laura Calzà
- Scaffold or substrate identification (nervous cells) - Luciana Giardino
- Isolation, target carachterisation (nervous cells) - Luciana Giardino
- In vitro and in vivo pre-clinical validation (nervous cells) - Maura Cescatti